Ontology highlight
ABSTRACT:
SUBMITTER: Zackular JP
PROVIDER: S-EPMC6697607 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Zackular Joseph P JP Kirk Leslie L Trindade Bruno C BC Skaar Eric P EP Aronoff David M DM
Anaerobe 20190617
Clostridium difficile infection (CDI) is one of the most common nosocomial infections worldwide and an urgent public health threat. Epidemiological and experimental studies have demonstrated an association between nonsteroidal anti-inflammatory drug (NSAID) exposure and enhanced susceptibility to, and severity of, CDI. NSAIDs target cyclooxygenase enzymes and inhibit the production of prostaglandins (PGs), but the therapeutic potential of exogenous introduction of PGs for the treatment of CDI ha ...[more]