Ontology highlight
ABSTRACT:
SUBMITTER: Pruitt HC
PROVIDER: S-EPMC6697628 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Pruitt Hawley C HC Lewis Daniel D Ciccaglione Mark M Connor Sydney S Smith Quinton Q Hickey John W JW Schneck Jonathan P JP Gerecht Sharon S
Matrix biology : journal of the International Society for Matrix Biology 20190216
Lymphocyte motility is governed by a complex array of mechanisms, and highly dependent on external microenvironmental cues. Tertiary lymphoid sites in particular have unique physical structure such as collagen fiber alignment, due to matrix deposition and remodeling. Three dimensional studies of human lymphocytes in such environments are lacking. We hypothesized that aligned collagenous environment modulates CD8+ T cells motility. We encapsulated activated CD8+ T cells in collagen hydrogels of d ...[more]