Ontology highlight
ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC6697747 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Huang Xiuping X Ye Qing Q Chen Min M Li Aimin A Mi Wenting W Fang Yuxin Y Zaytseva Yekaterina Y YY O'Connor Kathleen L KL Vander Kooi Craig W CW Liu Side S She Qing-Bai QB
Nature communications 20190816 1
Neuropilin-1 (NRP1) is an essential transmembrane receptor with a variety of cellular functions. Here, we identify two human NRP1 splice variants resulting from the skipping of exon 4 and 5, respectively, in colorectal cancer (CRC). Both NRP1 variants exhibit increased endocytosis/recycling activity and decreased levels of degradation, leading to accumulation on endosomes. This increased endocytic trafficking of the two NRP1 variants, upon HGF stimulation, is due to loss of N-glycosylation at th ...[more]