Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis.

ABSTRACT:

Background

Epidemiological observations have demonstrated that ambient fine particulate matter with d_p < 2.5 μm (PM_2.5) as the major factor responsible for the increasing incidence of lung cancer in never-smokers. However, there are very limited experimental data to support the association of PM_2.5 with lung carcinogenesis and to compare PM_2.5 with smoking carcinogens.

Methods

To study whether PM_2.5 can contribute to lung tumorigenesis in a way similar to smoking carcinogen 4-methylnitrosamino-l-3-pyridyl-butanone (NNK) via 15-lipoxygenases (15-LOXs) reduction, normal lung epithelial cells and cancer cells were treated with NNK or PM_2.5 and then epigenetically and post-translationally examined the cellular and

SUBMITTER: Li MY 

PROVIDER: S-EPMC6697918 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature