Ontology highlight
ABSTRACT:
SUBMITTER: Minner S
PROVIDER: S-EPMC6698296 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Minner Sarah S Hager Dominik D Steurer Stefan S Höflmayer Doris D Tsourlakis Maria Christina MC Möller-Koop Christina C Clauditz Till S TS Hube-Magg Claudia C Luebke Andreas M AM Simon Ronald R Sauter Guido G Göbel Cosima C Weidemann Sören S Lebok Patrick P Dum David D Fraune Christoph C Izbicki Jakob J Burandt Eike E Schlomm Thorsten T Huland Hartwig H Heinzer Hans H Haese Alexander A Graefen Markus M Heumann Asmus A
Neoplasia (New York, N.Y.) 20190802 9
Dysregulation of S100A8 is described in many different human tumor types, but its role in prostate cancer is unknown. To evaluate the clinical relevance of S100A8 expression in prostate cancer, a tissue microarray containing 13,665 tumors was analyzed by immunohistochemistry. Cytoplasmic S100A8 staining was compared to prostate cancer phenotype, patient prognosis and molecular features including TMPRSS2:ERG fusion status and deletions of PTEN, 3p, 5q and 6q. S100A8 immunostaining was typically s ...[more]