Dataset Information

U-shaped association between low-density lipid cholesterol and diabetes mellitus in patients with hypertension.

ABSTRACT:

Background

The magnitude and direction of association of low-density lipid cholesterol (LDL-C) with diabetes mellitus (DM) might differ by hypertensive status, but there is limited epidemiological evidence in China.

Methods

We examined the association between LDL-C levels and DM in 9892 participants with hypertension using logistic regression. Participants were stratified into three groups according to LDL-C levels (desirable, borderline high or high), then further divided into quartiles. Restricted cubic spline regression models, subgroup analysis and interaction tests were also conducted to evaluate the shape of association.

Results

After adjusting for covariates, lower LDL-C had a significant and inverse association with the likelihood of DM in all participants (OR: 0.944, 95% CI?=?0.893, 0.998). In participants with desirable LDL-C concentrations (?4.1?mmol/L), LDL-C increased the DM likelihood (OR?=?1.536, 95% CI?=?1.126, 2.096 per 1?mmol/L increase). Restricted cubic spline regression also found a U-shaped association between LDL-C levels and DM prevalence.

Conclusions

There was a U-shaped association between LDL-C levels and DM in Chinese patients with hypertension.

SUBMITTER: Liu L

PROVIDER: S-EPMC6698332 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

U-shaped association between low-density lipid cholesterol and diabetes mellitus in patients with hypertension.

Liu Lin L Shen Geng G Huang Jia-Yi JY Yu Yu-Ling YL Chen Chao-Lei CL Huang Yu-Qing YQ Feng Ying-Qing YQ

Lipids in health and disease 20190817 1

<h4>Background</h4>The magnitude and direction of association of low-density lipid cholesterol (LDL-C) with diabetes mellitus (DM) might differ by hypertensive status, but there is limited epidemiological evidence in China.<h4>Methods</h4>We examined the association between LDL-C levels and DM in 9892 participants with hypertension using logistic regression. Participants were stratified into three groups according to LDL-C levels (desirable, borderline high or high), then further divided into qu ...[more]

PMID: 31421673

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Project description:BackgroundSome previous studies on different populations have yielded inconsistent findings with respect to the relationship between levels of high-density lipoprotein cholesterol (HDL-C) and future type 2 diabetes mellitus (T2DM) incidence. This study was designed to gain further insight into this relationship through a cohort study with a 25-year follow-up duration.MethodsIn total, 1462 individuals that were 55 years of age or older and were free of T2DM at baseline were enrolled in the present study. T2DM incidence among this study population was detected through self-reported diagnoses or the concentration of fasting plasma glucose. The data were derived from nine surveys conducted from 1992 to 2017. The correlation between HDL-C levels and the T2DM risk was assessed through Cox proportional-hazards model and proportional hazards model for the sub-distribution with time-dependent variables.ResultsOver the follow-up period, 120 participants were newly diagnosed with new-onset T2DM. When research participants were separated into four groups on the basis for quartiles of their levels of HDL-C measured at baseline, and incidence of diabetes declined with higher baseline HDL-C levels at 12.60, 9.70, 5.38, and 5.22 per 1000 person-years, respectively. Adjusted hazard ratios (HRs) were 0.98 (95% confidence interval [CI]: 0.62-1.55), 0.48 (95% CI: 0.27-0.85) and 0.44 (95% CI: 0.25-0.80) for individuals with HDL-C levels within the 1.15-1.39, 1.40-1.69, and ≥ 1.70 mmol/L ranges relative to participants with HDL-C levels < 1.15 mmol/L. Multiple sensitivity analyses similarly revealed reduced risk of diabetes incidence with increased HDL-C levels. Incorporating the levels of HDL-C into a multivariate model significantly enhanced the overall power of the predictive model (P values were 0.0296, 0.0011, respectively, for 5- and 10-year risk of diabetes).ConclusionsLevels of HDL-C were independently and negatively associated with the risk of the new-onset T2DM among middle-aged and elderly Chinese.

Dataset Information

U-shaped association between low-density lipid cholesterol and diabetes mellitus in patients with hypertension.

Background

Methods

Results

Conclusions

Publications

U-shaped association between low-density lipid cholesterol and diabetes mellitus in patients with hypertension.

Similar Datasets

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