Ontology highlight
ABSTRACT:
SUBMITTER: van Holst RJ
PROVIDER: S-EPMC6698370 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
van Holst Ruth J RJ Sescousse Guillaume G Janssen Lieneke K LK Janssen Marcel M Berry Anne S AS Jagust William J WJ Cools Roshan R
Biological psychiatry 20170616 12
<h4>Background</h4>The hypothesis that dopamine plays an important role in the pathophysiology of pathological gambling is pervasive. However, there is little to no direct evidence for a categorical difference between pathological gamblers and healthy control subjects in terms of dopamine transmission in a drug-free state. Here we provide evidence for this hypothesis by comparing dopamine synthesis capacity in the dorsal and ventral parts of the striatum in 13 pathological gamblers and 15 health ...[more]