Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology.
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ABSTRACT:
SUBMITTER: Ayton S
PROVIDER: S-EPMC6698435 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology.
Ayton Scott S Wang Yamin Y Diouf Ibrahima I Schneider Julie A JA Brockman John J Morris Martha Clare MC Bush Ashley I AI
Molecular psychiatry 20190218 11
Cortical iron has been shown to be elevated in Alzheimer's disease (AD), but the impact of the directly measured iron on the clinical syndrome has not been assessed. We investigated the association between post-mortem iron levels with the clinical and pathological diagnosis of AD, its severity, and the rate of cognitive decline in the 12 years prior to death in subjects from the Memory and Aging Project (n = 209). Iron was elevated (β [SE] = 9.7 [2.6]; P = 3.0 × 10<sup>-4</sup>) in the inferior ...[more]
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