Ontology highlight
ABSTRACT:
SUBMITTER: Cristie-David AS
PROVIDER: S-EPMC6699099 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Cristie-David Ajitha S AS Marsh E Neil G ENG
Protein science : a publication of the Protein Society 20190806 9
Short, alpha-helical coiled coils provide a simple, modular method to direct the assembly of proteins into higher order structures. We previously demonstrated that by genetically fusing de novo-designed coiled coils of the appropriate oligomerization state to a natural trimeric protein, we could direct the assembly of this protein into various geometrical cages. Here, we have extended this approach by appending a coiled coil designed to trimerize in response to binding divalent transition metal ...[more]