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A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin.

ABSTRACT: A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested.

SUBMITTER: Reddeman RA

PROVIDER: S-EPMC6699309 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin.

Reddeman Robin A RA Glávits Róbert R Endres John R JR Clewell Amy E AE Hirka Gábor G Vértesi Adél A Béres Erzsébet E Szakonyiné Ilona Pasics IP

Journal of toxicology 20190801

A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using dos ...[more]

PMID: 31467524

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