Dataset Information

NOCTURNIN Gene Diurnal Variation in Healthy Volunteers and Expression Levels in Shift Workers.

ABSTRACT:

Objective

The NOCTURNIN gene links nutrient absorption and metabolism to the circadian clock. Shift workers are at a heightened risk of overweight and of developing obesity and metabolic syndrome. This study investigates the diurnal variation of NOCTURNIN in healthy volunteers and its expression levels in rotational shift and daytime workers.

Methods

NOCTURNIN expression levels were evaluated in peripheral blood lymphocytes from 15 healthy volunteers at 4-hour intervals for 24 h. Metabolic parameters and NOCTURNIN expression were measured in workers engaged in shift and daytime work.

Results

In the group of volunteers NOCTURNIN expression showed diurnal variation, with a peak at 8:00 AM. NOCTURNIN expression was higher in shift workers than in daytime workers. Multivariate analysis confirmed the role of shift work as an independent factor affecting NOCTURNIN expression. Notably, its level correlated directly with body mass index and inversely with total energy expenditure.

Conclusions

Measuring NOCTURNIN expression levels in human peripheral blood lymphocytes can improve investigations on the relationship between changes in circadian rhythm and metabolic disorders. Shift workers show higher NOCTURNIN levels than daytime workers.

SUBMITTER: Bracci M

PROVIDER: S-EPMC6699378 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

<i>NOCTURNIN</i> Gene Diurnal Variation in Healthy Volunteers and Expression Levels in Shift Workers.

Bracci Massimo M Copertaro Alfredo A Ciarapica Veronica V Barbaresi Mariella M Esposito Stefano S Albanesi Antonella A Valentino Matteo M Ledda Caterina C Rapisarda Venerando V Santarelli Lory L

BioMed research international 20190731

<h4>Objective</h4>The <i>NOCTURNIN</i> gene links nutrient absorption and metabolism to the circadian clock. Shift workers are at a heightened risk of overweight and of developing obesity and metabolic syndrome. This study investigates the diurnal variation of <i>NOCTURNIN</i> in healthy volunteers and its expression levels in rotational shift and daytime workers.<h4>Methods</h4><i>NOCTURNIN</i> expression levels were evaluated in peripheral blood lymphocytes from 15 healthy volunteers at 4-hour ...[more]

PMID: 31467910

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