Ontology highlight
ABSTRACT:
SUBMITTER: Tolkatchev D
PROVIDER: S-EPMC6699511 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Tolkatchev Dmitri D Elnatan Daniel D Nogara Leonardo L Ly Thu T Naber Nariman N Haak Kenny K Meech Ryan R Cooke Roger R Kostyukova Alla S AS
Archives of biochemistry and biophysics 20181002
Piperine, an alkaloid from black pepper, was found to inhibit the super-relaxed state (SRX) of myosin in fast-twitch skeletal muscle fibers. In this work we report that the piperine molecule binds heavy meromyosin (HMM), whereas it does not interact with the regulatory light chain (RLC)-free subfragment-1 (S1) or with control proteins from the same muscle molecular machinery, G-actin and tropomyosin. To further narrow down the location of piperine binding, we studied interactions between piperin ...[more]