Exploring the potential of deep-blue autofluorescence for monitoring amyloid fibril formation and dissociation.
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ABSTRACT:
SUBMITTER: Ziaunys M
PROVIDER: S-EPMC6699583 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Exploring the potential of deep-blue autofluorescence for monitoring amyloid fibril formation and dissociation.
Ziaunys Mantas M Sneideris Tomas T Smirnovas Vytautas V
PeerJ 20190816
Protein aggregation into amyloid fibrils has been linked to multiple neurodegenerative disorders. Determining the kinetics of fibril formation, as well as their structural stability are important for the mechanistic understanding of amyloid aggregation. Tracking both fibril association and dissociation is usually performed by measuring light scattering of the solution or fluorescence of amyloid specific dyes, such as thioflavin-T. A possible addition to these methods is the recently discovered d ...[more]
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