Striatal Dopamine Release in Response to Morphine: A [¹¹C]Raclopride Positron Emission Tomography Study in Healthy Men.

ABSTRACT:

Background

Preclinical and human positron emission tomography studies have produced inconsistent results regarding the effects of opioids on mesolimbic dopamine (DA). Here, we quantify striatal DA release (measured by [¹¹C]raclopride displacement) in response to an intravenous infusion of morphine, and its relationship with morphine-induced subjective effects, in healthy, nondependent opioid-experienced participants.

Methods

Fifteen healthy male participants were initially included. Sessions were on separate days. On session 1, participants received intravenous morphine (10 mg/70 kg) in the clinic to ensure tolerability. Participants without adverse reactions (n = 10) then received intravenous morphine and placebo (saline) sessions, in counterbalanced order, while

SUBMITTER: Spagnolo PA 

PROVIDER: S-EPMC6699765 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature