Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway.
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ABSTRACT:
SUBMITTER: Mullins EA
PROVIDER: S-EPMC6699911 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway.
Mullins Elwood A EA Rodriguez Alyssa A AA Bradley Noah P NP Eichman Brandt F BF
Trends in biochemical sciences 20190509 9
The base excision repair (BER) pathway historically has been associated with maintaining genome integrity by eliminating nucleobases with small chemical modifications. In the past several years, however, BER was found to play additional roles in genome maintenance and metabolism, including sequence-specific restriction modification and repair of bulky adducts and interstrand crosslinks. Central to this expanded biological utility are specialized DNA glycosylases - enzymes that selectively excise ...[more]
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