Ontology highlight
ABSTRACT:
SUBMITTER: Gorle AK
PROVIDER: S-EPMC6699998 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Dalton transactions (Cambridge, England : 2003) 20190701 26
Reported herein is a detailed NMR and DFT study of the interaction of the 15N-labelled dinuclear platinum anticancer compound [{cis-PtCl(NH3)2}2{μ-H2N(CH2)6NH2}]2+ (15N-1, 1,1/c,c) with 1,2-dihexanoyl-sn-glycero-3-phosphate (DHPA), as a comparison with an earlier study of the interaction of the same water-soluble phospholipid fragment with the geometric trans isomer (1,1/t,t). The reaction of 15N-1 with the sodium salt of DHPA was studied at 298 K, pH ∼ 5.6, by [1H,15N] HSQC 2D NMR spectroscopy. ...[more]