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Effects of remote ischemic conditioning on kidney injury in at-risk patients undergoing elective coronary angiography (PREPARE study): a multicenter, randomized clinical trial.


ABSTRACT: The ability of remote ischemic preconditioning (RIPC) to prevent contrast-induced nephropathy (CIN) following percutaneous coronary angiography in at-risk patients is controversial. No evidence exists regarding potential RIPC positive effects on renal function and clinical outcomes in the long-term. The PREPARE study was a randomized, prospective, multicenter, and double-blinded trial. A total of 222 patients scheduled for coronary angiography and/or percutaneous transluminal coronary angioplasty with an estimated glomerular filtration rate (eGFR)?

SUBMITTER: Roubille F 

PROVIDER: S-EPMC6700075 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Effects of remote ischemic conditioning on kidney injury in at-risk patients undergoing elective coronary angiography (PREPARE study): a multicenter, randomized clinical trial.

Roubille François F   Macia Jean-Christophe JC   Ivanes Fabrice F   Angoulvant Denis D   Mateus Victor V   Belle Loïc L   Elbaz Meyer M   Morel Olivier O   Furber Alain A   Bière Loïc L   Prunier Fabrice F  

Scientific reports 20190819 1


The ability of remote ischemic preconditioning (RIPC) to prevent contrast-induced nephropathy (CIN) following percutaneous coronary angiography in at-risk patients is controversial. No evidence exists regarding potential RIPC positive effects on renal function and clinical outcomes in the long-term. The PREPARE study was a randomized, prospective, multicenter, and double-blinded trial. A total of 222 patients scheduled for coronary angiography and/or percutaneous transluminal coronary angioplast  ...[more]

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