Ontology highlight
ABSTRACT:
SUBMITTER: Yarlagadda B
PROVIDER: S-EPMC6700112 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yarlagadda Bhavya B Kamatham Vaishnavi V Ritter Ashton A Shahjehan Faisal F Kasi Pashtoon M PM
NPJ precision oncology 20190819
Cholangiocarcinoma is a heterogeneous and target-rich disease with differences in actionable targets. Intrahepatic and extrahepatic types of cholangiocarcinoma differ significantly in clinical presentation and underlying genetic aberrations. Research has shown that extrahepatic cholangiocarcinoma is more likely to be associated with <i>ERBB2</i> (HER2) genetic aberrations. Various anti-HER2 clinical trials, case reports and other molecular studies show that HER2 is a real target in cholangiocarc ...[more]