Sex differences in mandibular repositioning device therapy effectiveness in patients with obstructive sleep apnea syndrome.

ABSTRACT: PURPOSE:Mandibular repositioning devices (MRDs) are an effective treatment option for obstructive sleep apnea syndrome (OSAS), particularly in patients who refuse or cannot tolerate continuous positive airway pressure (CPAP). However, sex differences in the response to therapy and predictors of response are not clearly defined. This analysis of data from the long-term prospective ORCADES trial compared MRD efficacy in men and women with OSAS. METHODS:The ORCADES study included patients with newly diagnosed mild-to-moderate or severe OSAS who refused or were non-compliant with CPAP. MRD therapy was titrated over 3-6 months. The primary endpoint was treatment success (??50% decrease in apnea-hypopnea index (AHI)). Complete response was defined using a range of AHI cut-off values (?30/h) were 100% and 68% (p =?0.0015). In women vs. men, overall complete response rates at AHI cut-off values of

SUBMITTER: Vecchierini MF 

PROVIDER: S-EPMC6700234 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature