Dataset Information
Focused transcranial ultrasound for treatment of neurodegenerative dementia.
Ontology highlight
ABSTRACT: Introduction
Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD).Methods
A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm2) affixed bilaterally was used to target the hippocampus (AD) or substantia nigra (PD) with functional magnetic resonance imaging navigation for enhanced plaque removal. A total of 22 patients (n = 11 AD, n = 11 PD) underwent 8 consecutive, weekly, 1-hour treatments wherein sleep was encouraged naturally or pharmacologically. Cognitive and motor functioning assessment was carried out using standardized evaluations at baseline and conclusion.Results
Of all, 62.5% of patients had one or more improved cognitive scores without data incongruence, 87% had stable or improved fine motor scores, and 87.5% had stable or improved gross motor scores. No adverse events were reported.Discussion
The safety of focused transcranial Doppler and possible enhancement in patient functioning were suggested by outcome data.
SUBMITTER: Nicodemus NE
PROVIDER: S-EPMC6700262 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Focused transcranial ultrasound for treatment of neurodegenerative dementia.
Alzheimer's & dementia (New York, N. Y.) 20190808
<h4>Introduction</h4>Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD).<h4>Methods</h4>A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm<sup>2</sup>) affixed bilaterally was used to target the hippocampus (AD) or substantia nigra (PD) with functional magnetic resonance imaging navigation for enhanced plaque removal. A total of 22 pa ...[more]