Ontology highlight
ABSTRACT:
SUBMITTER: Patterson JR
PROVIDER: S-EPMC6701176 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Patterson Joseph R JR Duffy Megan F MF Kemp Christopher J CJ Howe Jacob W JW Collier Timothy J TJ Stoll Anna C AC Miller Kathryn M KM Patel Pooja P Levine Nathan N Moore Darren J DJ Luk Kelvin C KC Fleming Sheila M SM Kanaan Nicholas M NM Paumier Katrina L KL El-Agnaf Omar M A OMA Sortwell Caryl E CE
Neurobiology of disease 20190702
Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system and motor deficits can be useful tools for Parkinson's disease (PD) research. The preformed fibril (PFF) synucleinopathy model in rodents generally displays these PD-relevant features, however, the magnitude and predictability of these events is far from established. We therefore sought to optimize the magnitude of α-syn accumulation and nig ...[more]