Ontology highlight
ABSTRACT:
SUBMITTER: Kaczmarczyk L
PROVIDER: S-EPMC6701817 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
PLoS biology 20190808 8
A deep understanding of how regulation of the multiple levels of gene expression in mammalian tissues give rise to complex phenotypes has been impeded by cellular diversity. A handful of techniques were developed to tag-select nucleic acids of interest in specific cell types, thereby enabling their capture. We expanded this strategy by developing the Tagger knock-in mouse line bearing a quad-cistronic transgene combining enrichment tools for nuclei, nascent RNA, translating mRNA, and mature micr ...[more]