Ontology highlight
ABSTRACT:
SUBMITTER: Tang Z
PROVIDER: S-EPMC6701867 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Tang Zhenyuan Z Takahashi Yoshinori Y He Haiyan H Hattori Tatsuya T Chen Chong C Liang Xinwen X Chen Han H Young Megan M MM Wang Hong-Gang HG
Cell reports 20190801 7
During autophagy, phagophores grow into double-membrane vesicles called autophagosomes, but the underlying mechanism remains unclear. Here, we show a critical role of Atg2A in phagophore expansion. Atg2A translocates to the phagophore at the mitochondria-associated ER membrane (MAM) through a C-terminal 45-amino acid domain that we have termed the MAM localization domain (MLD). Proteomic analysis identifies the outer mitochondrial membrane protein TOM40 as a MLD-interacting partner. The Atg2A-TO ...[more]