Ontology highlight
ABSTRACT:
SUBMITTER: Liu K
PROVIDER: S-EPMC6702053 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Liu Kai K Jones Sandra S Minis Adi A Rodriguez Jose J Molina Henrik H Steller Hermann H
Developmental cell 20190718 4
Protein degradation by the ubiquitin-proteasome system is critical for neuronal function. Neurons utilize microtubule-dependent molecular motors to allocate proteasomes to synapses, but how proteasomes are coupled to motors and how this is regulated to meet changing demand for protein breakdown remain largely unknown. We show that the conserved proteasome-binding protein PI31 serves as an adaptor to couple proteasomes with dynein light chain proteins (DYNLL1/2). The inactivation of PI31 inhibite ...[more]