Ontology highlight
ABSTRACT:
SUBMITTER: Molinari S
PROVIDER: S-EPMC6702073 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature chemical biology 20190812 9
We describe a synthetic genetic circuit for controlling asymmetric cell division in Escherichia coli in which a progenitor cell creates a differentiated daughter cell while retaining its original phenotype. Specifically, we engineered an inducible system that can bind and segregate plasmid DNA to a single position in the cell. Upon cell division, colocalized plasmids are kept by one and only one of the daughter cells. The other daughter cell receives no plasmid DNA and is irreversibly differenti ...[more]