Ontology highlight
ABSTRACT:
SUBMITTER: Patel SJ
PROVIDER: S-EPMC6702080 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Patel Sarju J SJ Frey Avery G AG Palenchar Daniel J DJ Achar Sooraj S Bullough Kimberly Z KZ Vashisht Ajay A Wohlschlegel James A JA Philpott Caroline C CC
Nature chemical biology 20190812 9
Hundreds of cellular proteins require iron cofactors for activity, and cells express systems for their assembly and distribution. Molecular details of the cytosolic iron pool used for iron cofactors are lacking, but iron chaperones of the poly(rC)-binding protein (PCBP) family play a key role in ferrous ion distribution. Here we show that, in cells and in vitro, PCBP1 coordinates iron via conserved cysteine and glutamate residues and a molecule of noncovalently bound glutathione (GSH). Proteomic ...[more]