Ontology highlight
ABSTRACT:
SUBMITTER: Vergara-Jaque A
PROVIDER: S-EPMC6702135 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Vergara-Jaque Ariela A Palma-Cerda Francisco F Lowet Adam S AS de la Cruz Landrau Angel A Poblete Horacio H Sukharev Alexander A Comer Jeffrey J Holmgren Miguel M
Biophysical journal 20190614 2
After opening, the Shaker voltage-gated potassium (K<sub>V</sub>) channel rapidly inactivates when one of its four N-termini enters and occludes the channel pore. Although it is known that the tip of the N-terminus reaches deep into the central cavity, the conformation adopted by this domain during inactivation and the nature of its interactions with the rest of the channel remain unclear. Here, we use molecular dynamics simulations coupled with electrophysiology experiments to reveal the atomic ...[more]