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Air pollution exposure associates with increased risk of neonatal jaundice.

ABSTRACT: Clinical experience suggests increased incidences of neonatal jaundice when air quality worsens, yet no studies have quantified this relationship. Here we reports investigations in 25,782 newborns showing an increase in newborn's bilirubin levels, the indicator of neonatal jaundice risk, by 0.076 (95% CI: 0.027-0.125), 0.029 (0.014-0.044) and 0.009 (95% CI: 0.002-0.016) mg/dL per ?g/m³ for PM_2.5 exposure in the concentration ranges of 10-35, 35-75 and 75-200??g/m³, respectively. The response is 0.094 (0.077-0.111) and 0.161 (0.07-0.252) mg/dL per ?g/m³ for SO₂ exposure at 10-15 and above 15??g/m³, respectively, and 0.351 (0.314-0.388) mg/dL per mg/m³ for CO exposure. Bilirubin levels increase linearly with exposure time between 0 and 48?h. Positive relationship between maternal exposure and newborn bilirubin level is also quantitated. The jaundice-pollution relationship is not affected by top-of-atmosphere incident solar irradiance and atmospheric visibility. Improving air quality may therefore be key to lowering the neonatal jaundice risk.

SUBMITTER: Zhang L

PROVIDER: S-EPMC6702167 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Air pollution exposure associates with increased risk of neonatal jaundice.

Zhang Liqiang L Liu Weiwei W Hou Kun K Lin Jintai J Song Changqing C Zhou Chenghu C Huang Bo B Tong Xiaohua X Wang Jinfeng J Rhine William W Jiao Ying Y Wang Ziwei Z Ni Ruijing R Liu Mengyao M Zhang Liang L Wang Ziye Z Wang Yuebin Y Li Xingang X Liu Suhong S Wang Yanhong Y

Nature communications 20190820 1

Clinical experience suggests increased incidences of neonatal jaundice when air quality worsens, yet no studies have quantified this relationship. Here we reports investigations in 25,782 newborns showing an increase in newborn's bilirubin levels, the indicator of neonatal jaundice risk, by 0.076 (95% CI: 0.027-0.125), 0.029 (0.014-0.044) and 0.009 (95% CI: 0.002-0.016) mg/dL per μg/m3 for PM2.5 exposure in the concentration ranges of 10-35, 35-75 and 75-200 μg/m3</sup ...[more]

PMID: 31431616

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Project description:ImportanceSeveral studies reported an association between peritonsillar abscess formation and climate conditions, including seasonal changes; however, the results were inconsistent.ObjectiveTo evaluate the association between meteorological conditions and/or air pollution and peritonsillar abscess formation.Design, setting, and participantsIn this nested case-control study, 3819 participants with peritonsillar abscesses were matched (1:4) for age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 15 276 control participants. The Korean Health Insurance Review and Assessment Service-National Sample Cohort (HIRA-NSC) data from 2002 through 2013 were used.Exposures and main outcomes and measuresThe meteorological data included the mean daily temperature (°C), highest daily temperature (°C), lowest daily temperature (°C), daily temperature difference (°C), relative humidity (%), spot atmospheric pressure (hPa), sulfur dioxide ([SO2], parts per million [ppm]), nitrogen dioxide (NO2, ppm), ozone (O3, ppm), carbon monoxide (CO, ppm), and particulate matter less than 10 μg (PM10, μg/m3) for the previous 14 days, 10 days, 7 days, 5 days, or 3 days before the matched index date. These factors were measured in 94 or 273 locations hourly. The crude and adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of meteorological data for peritonsillar abscess formation were analyzed using unconditional logistic regression analysis. Subgroup analyses were conducted according to age and sex.ResultsThe male to female ratio of study participants was 1.43 (11 260 to 7835). Because the age groups were classified using 5-year intervals, the mean age could not be defined. The mean differences of NO2 and PM10 concentrations for the 14 days between peritonsillar abscess group and control group were 1.78 ppb (95% CI, 1.47-2.09) and 1.33 μg/m3 (95% CI, 0.67-1.99), respectively. The aORs of NO2 (0.1 ppm) and PM10 (10 μg/m3) during the 14 days prior to the index date for peritonsillar abscess formation were 12.8 (95% CI, 8.4-19.5) and 1.04 (95% CI, 1.02-1.06), respectively. The other meteorological conditions did not reach statistical significance.Conclusions and relevancePeritonsillar abscess formation was associated with high concentrations of NO2 and PM10.

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Air pollution exposure associates with increased risk of neonatal jaundice.

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Air pollution exposure associates with increased risk of neonatal jaundice.

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