PEARL: A Non-interventional Study of Real-World Alirocumab Use in German Clinical Practice.

ABSTRACT:

Background

Several lipid guidelines recommend that proprotein convertase subtilisin/kexin type 9 inhibitors should be considered for patients with atherosclerotic cardiovascular disease who are inadequately treated with maximally tolerated lipid-lowering treatment.

Objectives

The PEARL study assessed the efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab in patients with hypercholesterolemia in a real-world setting.

Methods

PEARL was an open, prospective, multicenter, non-interventional study conducted in Germany. Patients (n = 619) for whom treating physicians decided to use alirocumab 75 or 150 mg every 2 weeks according to German guidelines (low-density lipoprotein cholesterol > 1.8/2.6 mmol/L [> 70/100 mg/dL], depending o

SUBMITTER: Parhofer KG 

PROVIDER: S-EPMC6702526 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature