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Oxidative Coupling of 3-Oxindoles with Indoles and Arenes.

ABSTRACT: A highly efficient method for the oxidative coupling of 2-substituted 3-oxindoles with aromatic compounds to form 2,2-disubstituted indolin-3-ones with broad scope is described. This work utilized oxygen as the terminal oxidant and a base-metal catalyst under mild conditions instead of toxic/precious-metal reagents and higher-molecular-weight oxidants. Quaternary structures were produced in modest-to-excellent yields (up to 96?%) without prefunctionalization.

SUBMITTER: Kang H

PROVIDER: S-EPMC6703824 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Oxidative Coupling of 3-Oxindoles with Indoles and Arenes.

Kang Houng H Jemison Adriana L AL Nigro Erin E Kozlowski Marisa C MC

ChemSusChem 20190527 13

A highly efficient method for the oxidative coupling of 2-substituted 3-oxindoles with aromatic compounds to form 2,2-disubstituted indolin-3-ones with broad scope is described. This work utilized oxygen as the terminal oxidant and a base-metal catalyst under mild conditions instead of toxic/precious-metal reagents and higher-molecular-weight oxidants. Quaternary structures were produced in modest-to-excellent yields (up to 96 %) without prefunctionalization. ...[more]

PMID: 30945447

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