Ontology highlight
ABSTRACT:
SUBMITTER: Park E
PROVIDER: S-EPMC6703900 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Park Eugene E Patel Swapneel S Wang Qiuling Q Andhey Prabhakar P Zaitsev Konstantin K Porter Sophia S Hershey Maxwell M Bern Michael M Plougastel-Douglas Beatrice B Collins Patrick P Colonna Marco M Murphy Kenneth M KM Oltz Eugene E Artyomov Maxim M Sibley L David LD Yokoyama Wayne M WM
eLife 20190808
Innate lymphoid cells (ILCs) were originally classified based on their cytokine profiles, placing natural killer (NK) cells and ILC1s together, but recent studies support their separation into different lineages at steady-state. However, tumors may induce NK cell conversion into ILC1-like cells that are limited to the tumor microenvironment and whether this conversion occurs beyond this environment remains unknown. Here, we describe <i>Toxoplasma gondii</i> infection converts NK cells into ILC1- ...[more]