Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses.

ABSTRACT: A central paradigm within virology is that each viral particle largely behaves as an independent infectious unit. Here, we demonstrate that clusters of enteroviral particles are packaged within phosphatidylserine (PS) lipid-enriched vesicles that are non-lytically released from cells and provide greater infection efficiency than free single viral particles. We show that vesicular PS lipids are co-factors to the relevant enterovirus receptors in mediating subsequent infectivity and transmission, in particular to primary human macrophages. We demonstrate that clustered packaging of viral particles within vesicles enables multiple viral RNA genomes to be collectively transferred into single cells. This study reveals a novel mode of viral transmission, where enteroviral genomes are transmitted

SUBMITTER: Chen YH 

PROVIDER: S-EPMC6704014 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature