Dataset Information

Impact of adaptive intensity-modulated radiotherapy on the neutrophil-to-lymphocyte ratio in patients with nasopharyngeal carcinoma.

ABSTRACT:

Purpose

Nutritional status and haematological parameters are related to the prognosis of patients treated with radiotherapy, but the correlation between adaptive radiotherapy (ART) and haematological indicators has never been reported. This study explores the influence of ART on the change in haematological indicators and provides a theoretical basis for the use of ART in patients with nasopharyngeal carcinoma (NPC).

Patients and methods

We retrospectively analysed 122 patients with NPC from January 2014 to December 2015. Patients in two treatment groups were matched using the propensity score matching method at a ratio of 1:1. The data were analysed with the Kaplan-Meier method, log-rank tests, regression analyses and paired t tests.

Results

Significant differences were detected for changes in the neutrophil-to-lymphocyte ratio (?NLR), circulating lymphocyte count (?CLC), circulating platelet count (?CPC), and circulating neutrophil granulocyte count (?CNC) during radiotherapy (P?=?0.002, P?ConclusionART ameliorates changes in haematological indexes (?NLR, ?CLC, and ?CPC) and reduces side effects to the skin and PGs and weight loss during radiotherapy in patients with NPC, and patients with stage T1-2 disease experience a greater benefit.

SUBMITTER: Han N

PROVIDER: S-EPMC6704552 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Impact of adaptive intensity-modulated radiotherapy on the neutrophil-to-lymphocyte ratio in patients with nasopharyngeal carcinoma.

Han Ning N Lyu Xintong X Li Guang G Qiao Qiao Q

Radiation oncology (London, England) 20190822 1

<h4>Purpose</h4>Nutritional status and haematological parameters are related to the prognosis of patients treated with radiotherapy, but the correlation between adaptive radiotherapy (ART) and haematological indicators has never been reported. This study explores the influence of ART on the change in haematological indicators and provides a theoretical basis for the use of ART in patients with nasopharyngeal carcinoma (NPC).<h4>Patients and methods</h4>We retrospectively analysed 122 patients wi ...[more]

PMID: 31438994

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Project description:BACKGROUND:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy (IMRT) as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma (NPC), but the radiation-related complications and relatively high medical costs remain a consequential burden for the patients. Endoscopic nasopharyngectomy (ENPG) was successfully applied in recurrent NPC with radiation free and relatively low medical costs. In this study, we examined whether ENPG could be an effective treatment for localized stage I NPC. METHODS:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer Center. Simultaneously, the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference cohort. The survival outcomes, quality of life (QOL), and medical costs between two groups were compared. RESULTS:After a median follow-up of 59.0 months (95% CI 53.4-64.6), no death, locoregional recurrence, or distant metastasis was observed in the 10 patients treated with ENPG. The 5-year overall survival, local relapse-free survival, regional relapse-free survival, and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients (100% vs. 99.1%, 100% vs. 97.7%, 100% vs. 99.0%, 100% vs. 97.4%, respectively, P?>?0.05). In addition, compared with IMRT, ENPG was associated with decreased total medical costs ($ 4090.42?±?1502.65 vs. $ 12620.88?±?4242.65, P?<?0.001) and improved QOL scores including dry mouth (3.3?±?10.5 vs. 34.4?±?25.8, P?<?0.001) and sticky saliva (3.3?±?10.5 vs. 32.6?±?23.3, P?<?0.001). CONCLUSIONS:ENPG alone was associated with promising long-term survival outcomes, low medical costs, and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused radiotherapy. However, the application of ENPG should be prudent, and prospective clinical trials were needed to further verify the results.

Dataset Information

Impact of adaptive intensity-modulated radiotherapy on the neutrophil-to-lymphocyte ratio in patients with nasopharyngeal carcinoma.

Purpose

Patients and methods

Results

Publications

Impact of adaptive intensity-modulated radiotherapy on the neutrophil-to-lymphocyte ratio in patients with nasopharyngeal carcinoma.

Similar Datasets

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