CD33 splice site genotype was not associated with outcomes of patients receiving the anti-CD33 drug conjugate SGN-CD33A.
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ABSTRACT:
SUBMITTER: Stanchina M
PROVIDER: S-EPMC6704571 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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CD33 splice site genotype was not associated with outcomes of patients receiving the anti-CD33 drug conjugate SGN-CD33A.
Stanchina Michele M Pastore Alessandro A Devlin Sean S Famulare Christopher C Stein Eytan E Taylor Justin J
Journal of hematology & oncology 20190822 1
We tested whether a single nucleotide polymorphism (SNP) that affects splicing of CD33 predicted response to treatment in adults with acute myeloid leukemia (AML) who received the novel CD33 antibody-drug conjugate SGN-CD33A. This genotype, for the CD33 splice site SNP rs12459419, was not associated with clinical response (30% CR/CRi in both groups), event-free survival, or overall survival. ...[more]
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