Ontology highlight
ABSTRACT:
SUBMITTER: Zheng D
PROVIDER: S-EPMC6705112 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zheng Dong D Zhang Yi Y Zheng Ming M Cao Ting T Wang Grace G Zhang Lulu L Ni Rui R Brockman Joseph J Zhong Huiting H Fan Guo-Chang GC Peng Tianqing T
Clinical science (London, England : 1979) 20190715 13
Doxorubicin (DOX) is widely used as a first-line chemotherapeutic drug for various malignancies. However, DOX causes severe cardiotoxicity, which limits its clinical uses. Oxidative stress is one of major contributors to DOX-induced cardiotoxicity. While autophagic flux serves as an important defense mechanism against oxidative stress in cardiomyocytes, recent studies have demonstrated that DOX induces the blockage of autophagic flux, which contributes to DOX cardiotoxicity. The present study in ...[more]