Ontology highlight
ABSTRACT:
SUBMITTER: Lacagnina AF
PROVIDER: S-EPMC6705137 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Lacagnina Anthony F AF Brockway Emma T ET Crovetti Chelsea R CR Shue Francis F McCarty Meredith J MJ Sattler Kevin P KP Lim Sean C SC Santos Sofia Leal SL Denny Christine A CA Drew Michael R MR
Nature neuroscience 20190401 5
Learned fear often relapses after extinction, suggesting that extinction training generates a new memory that coexists with the original fear memory; however, the mechanisms governing the expression of competing fear and extinction memories remain unclear. We used activity-dependent neural tagging to investigate representations of fear and extinction memories in the dentate gyrus. We demonstrate that extinction training suppresses reactivation of contextual fear engram cells while activating a s ...[more]