Ontology highlight
ABSTRACT:
SUBMITTER: Zhu JS
PROVIDER: S-EPMC6705401 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20190404 15
The Cadogan cyclization is a robust but harsh method for the synthesis of 2 H-indazoles, a valuable class of nitrogen heterocycles. Although nitrene generation by exhaustive deoxygenation is widely accepted as the operating mechanism in the reductive cyclization of nitroaromatics, non-nitrene pathways have only been theorized previously. Here, 2 H-indazole N-oxides were synthesized through an interrupted Cadogan/Davis-Beirut reaction and are presented as direct evidence of competent oxygenated i ...[more]