Ontology highlight
ABSTRACT:
SUBMITTER: Lewkowicz P
PROVIDER: S-EPMC6705439 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Lewkowicz Przemysław P Cwiklińska Hanna H Mycko Marcin P MP Cichalewska Maria M Domowicz Małgorzata M Lewkowicz Natalia N Jurewicz Anna A Selmaj Krzysztof W KW
The Journal of neuroscience : the official journal of the Society for Neuroscience 20150501 19
MicroRNAs (miRNAs) associate with Argonaute (Ago), GW182, and FXR1 proteins to form RNA-induced silencing complexes (RISCs). RISCs represent a critical checkpoint in the regulation and bioavailability of miRNAs. Recent studies have revealed dysregulation of miRNAs in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE); however, the function of RISCs in EAE and MS is largely unknown. Here, we examined the expression of Ago, GW182, and FXR1 in CNS tissue, ...[more]