Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC6706008 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhang Jingbo J Koussih Latifa L Shan Lianyu L Halayko Andrew J AJ Tliba Omar O Gounni Abdelilah S AS
PloS one 20190822 8
Pentraxin-3 (PTX3) is a multifunctional protein involved in both innate and adaptive immunity. Glucocorticoid (GC) is the first-line therapy to mitigate airway inflammation in asthma. Previous pieces of evidence showed that GC has divergent effects on PTX3 production in various cell types. The molecular mechanisms controlling PTX3 expression in HASMC are, however, not yet characterized. In this study, we demonstrate that the synthetic GC, dexamethasone (DEX) increases the expression of PTX3 both ...[more]