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Making and breaking heme.


ABSTRACT: Mechanisms for making and breaking the heme b cofactor (heme) are more diverse than previously expected. Biosynthetic pathways have diverged at least twice along taxonomic lines, reflecting differences in membrane organization and O2 utilization among major groups of organisms. At least three families of heme degradases are now known, again differing in whether and how O2 is used by the organism and possibly the purpose for turning over the tetrapyrrole. Understanding these enzymes and pathways offers a handle for antimicrobial development and for monitoring heme use in organismal and ecological systems.

SUBMITTER: Celis AI 

PROVIDER: S-EPMC6706330 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Making and breaking heme.

Celis Arianna I AI   DuBois Jennifer L JL  

Current opinion in structural biology 20190222


Mechanisms for making and breaking the heme b cofactor (heme) are more diverse than previously expected. Biosynthetic pathways have diverged at least twice along taxonomic lines, reflecting differences in membrane organization and O<sub>2</sub> utilization among major groups of organisms. At least three families of heme degradases are now known, again differing in whether and how O<sub>2</sub> is used by the organism and possibly the purpose for turning over the tetrapyrrole. Understanding these  ...[more]

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