Posttranslational Regulation of IL-23 Production Distinguishes the Innate Immune Responses to Live Toxigenic versus Heat-Inactivated Vibrio cholerae.
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ABSTRACT:
SUBMITTER: Weil AA
PROVIDER: S-EPMC6706466 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Posttranslational Regulation of IL-23 Production Distinguishes the Innate Immune Responses to Live Toxigenic versus Heat-Inactivated Vibrio cholerae.
Weil Ana A AA Ellis Crystal N CN Debela Meti D MD Bhuiyan Taufiqur R TR Rashu Rasheduzzaman R Bourque Daniel L DL Khan Ashraful I AI Chowdhury Fahima F LaRocque Regina C RC Charles Richelle C RC Ryan Edward T ET Calderwood Stephen B SB Qadri Firdausi F Harris Jason B JB
mSphere 20190821 4
<i>Vibrio cholerae</i> infection provides long-lasting protective immunity, while oral, inactivated cholera vaccines (OCV) result in more-limited protection. To identify characteristics of the innate immune response that may distinguish natural <i>V. cholerae</i> infection from OCV, we stimulated differentiated, macrophage-like THP-1 cells with live versus heat-inactivated <i>V. cholerae</i> with and without endogenous or exogenous cholera holotoxin (CT). Interleukin 23A gene (<i>IL23A</i>) expr ...[more]
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