The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation.
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ABSTRACT:
SUBMITTER: Zou Y
PROVIDER: S-EPMC6706956 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
The DNA Methylation Inhibitor Zebularine Controls CD4<sup>+</sup> T Cell Mediated Intraocular Inflammation.
Zou Yanli Y Hu Xiao X Schewitz-Bowers Lauren P LP Stimpson Madeleine M Miao Li L Ge Xiaofei X Yang Liu L Li Yan Y Bible Paul W PW Wen Xiaofeng X Li Jing Jing JJ Liu Yizhi Y Lee Richard W J RWJ Wei Lai L
Frontiers in immunology 20190816
CD4<sup>+</sup> T cell mediated uveitis is conventionally treated with systemic immunosuppressive agents, including corticosteroids and biologics targeting key inflammatory cytokines. However, their long-term utility is limited due to various side effects. Here, we investigated whether DNA methylation inhibitor zebularine can target CD4<sup>+</sup> T cells and control intraocular inflammation. Our results showed that zebularine restrained the expression of inflammatory cytokines IFN-γ and IL-17 ...[more]
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