Ontology highlight
ABSTRACT:
SUBMITTER: Gao GF
PROVIDER: S-EPMC6707074 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Cell systems 20190701 1
We present a systematic analysis of the effects of synchronizing a large-scale, deeply characterized, multi-omic dataset to the current human reference genome, using updated software, pipelines, and annotations. For each of 5 molecular data platforms in The Cancer Genome Atlas (TCGA)-mRNA and miRNA expression, single nucleotide variants, DNA methylation and copy number alterations-comprehensive sample, gene, and probe-level studies were performed, towards quantifying the degree of similarity bet ...[more]