Ontology highlight
ABSTRACT:
SUBMITTER: Zhang EX
PROVIDER: S-EPMC6707087 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in chemistry 20190816
A number of hydroxyl-substituted azacalix[4]pyridines were synthesized using Pd-catalyzed macrocyclic "2+2" and "3+1" coupling methods and the protection-deprotection strategy of hydroxyl group. While the conformation of the these hydroxyl-substituted azacalix[4]pyridines is fluxional in solution, in the solid state, they adopted shape-persistent 1,3-alternate conformations. Besides, X-ray analysis revealed that the existence of hydroxy groups on the <i>para</i>-position of pyridine facilitated ...[more]