Ontology highlight
ABSTRACT:
SUBMITTER: Yong T
PROVIDER: S-EPMC6707218 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Yong Tuying T Zhang Xiaoqiong X Bie Nana N Zhang Hongbo H Zhang Xuting X Li Fuying F Hakeem Abdul A Hu Jun J Gan Lu L Santos Hélder A HA Yang Xiangliang X
Nature communications 20190823 1
Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy. Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis of the endocytosed DOX-loaded PSiNPs from tumor cells, exhibit enhanced tumor accumulation, extravasation from blood vessels an ...[more]