Ontology highlight
ABSTRACT:
SUBMITTER: Maura F
PROVIDER: S-EPMC6707220 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature communications 20190823 1
The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using sequences from 67 MM genomes serially collected from 30 patients together with public exome datasets. Bayesian clustering defines at least 7 genomic subgroups with distinct sets of co-operating events. Focusing on whole genome sequencing data, complex structural events emerge as major drivers, including chromothripsis and a no ...[more]