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Impact of depression on clinical outcomes following percutaneous coronary intervention: a systematic review and meta-analysis.


ABSTRACT:

Objectives

The objective of this meta-analysis was to assess whether depression in percutaneous coronary intervention (PCI) patients is associated with higher risk of adverse outcomes.

Design

Systematic review and meta-analysis.

Methods

EMBASE, PubMed, CINAHL and PsycINFO were searched as data sources. We selected prospective cohort studies evaluating the relationship between depression and any adverse medical outcome, including all-cause mortality, cardiac mortality and non-fatal events, from inception to 28 February 2019. Two reviewers independently extracted information and calculated the risk of cardiovascular events in patients with preoperative or postoperative depression compared with non-depressed patients.

Results

Eight studies (n=3297) met our inclusion criteria. Most studies found a positive association between depression and adverse cardiovascular outcomes. Meta-analysis yielded an aggregate risk ratio of 1.57 (95% CI 1.28 to 1.92, p<0.0001) for the magnitude of the relation between depression and adverse outcomes.

Conclusions

Our systematic review and meta-analysis suggests that depression is associated with an increased risk of worse clinical outcome or mortality in patients undergoing PCI. Assessment time and length of follow-up do not have a significant effect on this conclusion.

SUBMITTER: Zhang WY 

PROVIDER: S-EPMC6707663 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Impact of depression on clinical outcomes following percutaneous coronary intervention: a systematic review and meta-analysis.

Zhang Wen Yi WY   Nan Nan N   Song Xian Tao XT   Tian Jin Fan JF   Yang Xue Yao XY  

BMJ open 20190820 8


<h4>Objectives</h4>The objective of this meta-analysis was to assess whether depression in percutaneous coronary intervention (PCI) patients is associated with higher risk of adverse outcomes.<h4>Design</h4>Systematic review and meta-analysis.<h4>Methods</h4>EMBASE, PubMed, CINAHL and PsycINFO were searched as data sources. We selected prospective cohort studies evaluating the relationship between depression and any adverse medical outcome, including all-cause mortality, cardiac mortality and no  ...[more]

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