Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC6707727 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Li Jinyang J Byrne Katelyn T KT Yan Fangxue F Yamazoe Taiji T Chen Zeyu Z Baslan Timour T Richman Lee P LP Lin Jeffrey H JH Sun Yu H YH Rech Andrew J AJ Balli David D Hay Ceire A CA Sela Yogev Y Merrell Allyson J AJ Liudahl Shannon M SM Gordon Naomi N Norgard Robert J RJ Yuan Salina S Yu Sixiang S Chao Timothy T Ye Shuai S Eisinger-Mathason T S Karin TSK Faryabi Robert B RB Tobias John W JW Lowe Scott W SW Coussens Lisa M LM Wherry E John EJ Vonderheide Robert H RH Stanger Ben Z BZ
Immunity 20180626 1
The biological and functional heterogeneity between tumors-both across and within cancer types-poses a challenge for immunotherapy. To understand the factors underlying tumor immune heterogeneity and immunotherapy sensitivity, we established a library of congenic tumor cell clones from an autochthonous mouse model of pancreatic adenocarcinoma. These clones generated tumors that recapitulated T cell-inflamed and non-T-cell-inflamed tumor microenvironments upon implantation in immunocompetent mice ...[more]