Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet.
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ABSTRACT:
SUBMITTER: Bisanz JE
PROVIDER: S-EPMC6708278 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet.
Bisanz Jordan E JE Upadhyay Vaibhav V Turnbaugh Jessie A JA Ly Kimberly K Turnbaugh Peter J PJ
Cell host & microbe 20190716 2
Multiple research groups have shown that diet impacts the gut microbiome; however, variability in experimental design and quantitative assessment have made it challenging to assess the degree to which similar diets have reproducible effects across studies. Through an unbiased subject-level meta-analysis framework, we re-analyzed 27 dietary studies including 1,101 samples from rodents and humans. We demonstrate that a high-fat diet (HFD) reproducibly changes gut microbial community structure. Fin ...[more]
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