Dataset Information

A rectified factor network based biclustering method for detecting cancer-related coding genes and miRNAs, and their interactions.

ABSTRACT: Detecting cancer-related genes and their interactions is a crucial task in cancer research. For this purpose, we proposed an efficient method, to detect coding genes, microRNAs (miRNAs), and their interactions related to a particular cancer or a cancer subtype using their expression data from the same set of samples. Firstly, biclusters specific to a particular type of cancer are detected based on rectified factor networks and ranked according to their associations with general cancers. Secondly, coding genes and miRNAs in each bicluster are prioritized by considering their differential expression and differential correlation values, protein-protein interaction data, and potential cancer markers. Finally, a rank fusion process is used to obtain the final comprehensive rank by combining multiple ranking results. We applied our proposed method on breast cancer datasets. Results show that our method outperforms other methods in detecting breast cancer-related coding genes and miRNAs. Furthermore, our method is very efficient in computing time, which can handle tens of thousands genes/miRNAs and hundreds of patients in hours on a desktop. This work may aid researchers in studying the genetic architecture of complex diseases, and improving the accuracy of diagnosis.

SUBMITTER: Su L

PROVIDER: S-EPMC6708461 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

A rectified factor network based biclustering method for detecting cancer-related coding genes and miRNAs, and their interactions.

Su Lingtao L Liu Guixia G Wang Juexin J Xu Dong D

Methods (San Diego, Calif.) 20190521

Detecting cancer-related genes and their interactions is a crucial task in cancer research. For this purpose, we proposed an efficient method, to detect coding genes, microRNAs (miRNAs), and their interactions related to a particular cancer or a cancer subtype using their expression data from the same set of samples. Firstly, biclusters specific to a particular type of cancer are detected based on rectified factor networks and ranked according to their associations with general cancers. Secondly ...[more]

PMID: 31121299

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Project description:BackgroundThe rapid advance in large-scale SNP-chip technologies offers us great opportunities in elucidating the genetic basis of complex diseases. Methods for large-scale interactions analysis have been under development from several sources. Due to several difficult issues (e.g., sparseness of data in high dimensions and low replication or validation rate), development of fast, powerful and robust methods for detecting various forms of gene-gene interactions continues to be a challenging task.Methodology/principal findingsIn this article, we have developed an evolution-based method to search for genome-wide epistasis in a case-control design. From an evolutionary perspective, we view that human diseases originate from ancient mutations and consider that the underlying genetic variants play a role in differentiating human population into the healthy and the diseased. Based on this concept, traditional evolutionary measure, fixation index (Fst) for two unlinked loci, which measures the genetic distance between populations, should be able to reveal the responsible genetic interplays for disease traits. To validate our proposal, we first investigated the theoretical distribution of Fst by using extensive simulations. Then, we explored its power for detecting gene-gene interactions via SNP markers, and compared it with the conventional Pearson Chi-square test, mutual information based test and linkage disequilibrium based test under several disease models. The proposed evolution-based method outperformed these compared methods in dominant and additive models, no matter what the disease allele frequencies were. However, its performance was relatively poor in a recessive model. Finally, we applied the proposed evolution-based method to analysis of a published dataset. Our results showed that the P value of the Fst -based statistic is smaller than those obtained by the LD-based statistic or Poisson regression models.Conclusions/significanceWith rapidly growing large-scale genetic association studies, the proposed evolution-based method can be a promising tool in the identification of epistatic effects.

Dataset Information

A rectified factor network based biclustering method for detecting cancer-related coding genes and miRNAs, and their interactions.

Publications

A rectified factor network based biclustering method for detecting cancer-related coding genes and miRNAs, and their interactions.

Similar Datasets

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